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Coiffier B et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002;346(4):235-42. Abstract

Forstpointner R et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood 2004;104(10):3064-71. Abstract

Habermann TM et al. Rituximab-CHOP versus CHOP with or without maintenance rituximab in patients 60 years of age or older with diffuse large B-cell lymphoma (DLBCL): An update. Proc ASH 2004;Abstract 127.

Hiddemann W et al. Rituximab maintenance following a rituximab containing chemotherapy significantly prolongs the duration of response in patients with relapsed follicular and mantle cell lymphomas: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). Proc ASCO 2005;Abstract 6527.

Hiddemann W et al. The addition of rituximab to combination chemotherapy with CHOP has a long lasting impact on subsequent treatment in remission in follicular lymphoma but not in mantle cell lymphoma: Results of two prospective randomized studies of the German Low Grade Lymphoma Study Group (GLSG). Proc ASH 2004;Abstract 161.

Marcus R et al. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood 2005;105(4):1417-23. Abstract

Van Oers MHJ et al. Chimeric anti-CD20 monoclonal antibody (rituximab; Mabtheraâ) in remission induction and maintenance treatment of relapsed/resistant follicular non-Hodgkin’s lymphoma: A phase III randomized Intergroup clinical trial. Proc ASH 2004;Abstract 586.

 

 

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Editor’s Note:
Is overall survival the only important endpoint in Phase III randomized clinical trials?
 
Bruce D Cheson, MD
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Myron S Czuczman, MD
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James O Armitage, MD
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